Inhalation & intravenous: umbilical cord mesenchymal stem cell-derived exosomes therapy strategy for acute respiratory distress syndrome in a murine model

The dual-route administration of umbilical cord MSC-exo is more effective in controlling the inflammatory response and alleviating lung injury in LPS-induced ARDS animal models. Inhalation rapidly alleviates pulmonary inflammation with a smaller dose, while intravenous injection better manages the systemic inflammation. This dual-route approach holds promise as a novel ARDS treatment strategy.