Factors influencing optimization of polyelectrolyte complex as raft systems containing ondansetron hydrochloride

Gastroretentive drug delivery systems (GRDDSs) are highly promising methods for the enhancement of the bioavailability and therapeutic effectiveness of some orally administered medications. The present review focused on gastroretentive film drug delivery methods, specifically developed to extend the duration of medication presence in the stomach which is most likely to enhance their absorption and efficacy. HCl release by evaluating key formulation and process parameters. The complexation technique was used to prepare PEC by adjusting Chitosan molecular weight and cross-linker concentration (1% and 2%). Formulations were assessed for drug content, buoyancy, raft strength, and in vitro drug release. Analytical methods such as FTIR, DSC, and FE-SEM confirmed PEC formation and structural properties. Drug release kinetics were modeled using mathematical equations. The finding demonstrates that increased Chitosan molecular weight and cross-linker concentration improved raft stability, buoyancy, and drug release control. The optimal formulation (F6) showed high drug content (94.8%), drug loading (11.9%), and sustained drug release over 12 hours. In conclusion, the optimized PEC raft system effectively prolonged Ond. HCl release offers a promising platform for drugs requiring extended gastric retention and controlled release.