Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammator
Patients with the MRS pLP spectrum showed reduced quality of life and upregulation of the lipid droplets-IL-17 inflammatory pathway in nucleus pulposus cells. Inflammatory factors contribute significantly to chronic low back pain development and progression, affecting patient-reported symptoms. The MRS lipids peak may serve as a potential biomarker for diagnosing and monitoring low back pain.
Authors
- Shiqi Tu (ORCID: https://orcid.org/0000-0003-3534-5714)
- Yongjin Li (ORCID: https://orcid.org/0000-0002-8073-2724)
- Jinlong Hu
- Chuanfu Li (ORCID: https://orcid.org/0000-0002-3023-9755)
- Yu Dong (ORCID: https://orcid.org/0000-0003-1774-1553)
- Xi Chen (ORCID: https://orcid.org/0000-0002-8523-3967)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7800-3189)
- Jiang Jiang (ORCID: https://orcid.org/0000-0001-9092-8301)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Huangshan University (CN)
- Anhui Xinhua University (CN)
Publication Details
- Journal
- Neurospine
- Published
- 2025-12-30
- DOI
- https://doi.org/10.14245/ns.2519750.395
- Citations
- 2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.94