Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum
Our findings establish the LPCAT1-PC axis as a potential protective mechanism against IDD by maintaining lysosomal homeostasis through interorganellar lipid trafficking. This study provides the first evidence linking lysosomal lipid composition, membrane stability, and ferroptosis in NP cells, offering new therapeutic strategies targeting lipid metabolism and organelle crosstalk for IDD management.
Authors
- Shiqi Tu (ORCID: https://orcid.org/0000-0003-3534-5714)
- Chuanfu Li (ORCID: https://orcid.org/0000-0002-3023-9755)
- Yu Dong (ORCID: https://orcid.org/0000-0003-1774-1553)
- Jiang Jiang (ORCID: https://orcid.org/0000-0001-9092-8301)
- Xi Chen
- Wenzhi Zhang
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Huangshan University (CN)
Publication Details
- Journal
- Neurospine
- Published
- 2025-12-30
- DOI
- https://doi.org/10.14245/ns.2550918.459
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00