Genetic evidence for the causal relationship between cerebrospinal fluid metabolites and intracranial aneurysms: A bidirectional two-sample Mendelian Randomization study

This study, through bidirectional MR analysis, uncovered the causal relationship between CSF metabolites and IA, highlighting the significant roles of various amino acids and lipid metabolites in the pathophysiology of IA. These metabolites not only provide new insights into the mechanisms underlying IA but also present potential biomarkers and therapeutic targets, offering theoretical support for early intervention and prevention strategies for the disease.