Quantitative analysis for identifying molecular subtypes of small cell lung cancer via two-dimensional and three-dimensional contrast-enhanced computed tomography images: a preliminary study

Quantitative analysis of CECT images via radiomics can noninvasively distinguish NE and non-NE molecular subtypes of SCLC. A simplified 2D radiomics approach performed comparably to 3D volumetric analysis for subtype classification and also demonstrated prognostic relevance. Radiomics could serve as a valuable adjunct for SCLC subtype identification and risk stratification, potentially guiding more personalized treatment decisions.