Impact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA)
rs5050(T > G) is associated with circulating angiotensinogen levels, but rs5050(T > G) alleles do not influence the relationship between estradiol and angiotensinogen. This suggests that estrogen's effect on angiotensinogen regulation occurs independently of rs5050(T > G), despite its location within an estrogen-responsive element.
Authors
- Andrew P. DeFilippis (ORCID: https://orcid.org/0000-0002-5135-9748)
- Patrick J. Trainor (ORCID: https://orcid.org/0000-0002-3012-9716)
- Xiuqing Guo (ORCID: https://orcid.org/0000-0002-5264-5068)
- Erin Morgan
- Sotirios Tsimikas
- Shubham Tomar (ORCID: https://orcid.org/0009-0008-9910-9300)
- Erin D. Michos
- Jerome I. Rotter
- Karita C. F. Lidani
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Ionis Pharmaceuticals (United States) (US)
- UCLA Medical Center (US)
- University of California San Diego (US)
- Harbor–UCLA Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1371/journal.pone.0339786
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00