Pulsed radiofrequency attenuates mechanical hypersensitivity in neuropathic pain rats by activating the Nrf2-regulated CaMKII/NF-ΚB signaling pathway
A novel therapeutic method employing high-voltage, long-duration PRF markedly ameliorated neuropathy, relieving central sensitization by activating the Nrf2 expression-regulated CaMKII/NF-κB signaling pathway blocking Ca<sup>2+</sup> pain signal transmission.
Authors
- Xue Yu
- Xiuyuan Fan
Institutions
- Liaoning Provincial People's Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- The Korean journal of pain
- Published
- 2025-12-31
- DOI
- https://doi.org/10.3344/kjp.25236
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University