Postpartum maternal monitoring for renal safety related to tenofovir exposure during breastfeeding in the PROMISE 1077BF randomized trial
Although participants randomized to TDF-ART had larger decreases in CrCl from Entry compared with participants randomized to iNVP, differences attenuated overtime and were not clinically significant. TDF-containing ART had no observed safety concerns for maternal renal function during the postpartum period.
Authors
- Lynette H. Nyakudya
- Teacler Nematadzira (ORCID: https://orcid.org/0000-0003-4786-1396)
- Jeanne De Jager (ORCID: https://orcid.org/0009-0005-2609-8602)
- Taha E. Taha (ORCID: https://orcid.org/0000-0001-9814-4894)
- Maxensia Owor
- Kathleen George
- George K. Siberry (ORCID: https://orcid.org/0000-0002-5999-1596)
- Kristin Baltrusaitis (ORCID: https://orcid.org/0000-0003-2090-9513)
- Barbara Heckman (ORCID: https://orcid.org/0000-0002-2289-7387)
- Mary Glenn Fowler (ORCID: https://orcid.org/0000-0003-4484-9009)
- Camlin Tierney
- Kevin Knowles
- for the PROMISE P1084s Study Team
- Lynda Stranix-Chibanda
- Renee Browning
- Haseena Cassim
Institutions
- Family Health International 360 (US)
- National Institutes of Health (US)
- Johns Hopkins University (US)
- University of Zimbabwe (ZW)
- University of the Witwatersrand (ZA)
- Stellenbosch University (ZA)
- Columbia University Irving Medical Center (US)
- Cancer Research And Biostatistics (US)
- MUJHU Research Collaboration (UG)
- National Institute of Allergy and Infectious Diseases (US)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Perinatal HIV Research Unit (ZA)
Publication Details
- Journal
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1097/qai.0000000000003829
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00