Brain-rejuvenating factor TIMP2 is associated with brain health and neuroprotective lifestyle in aged subjects
TIMP2 demonstrates clinical relevance for brain aging in humans and may represent a mechanism through which lifestyle behaviors confer neuroprotection. Further examination of TIMP2 as a potential therapeutic target for prevention of cognitive decline is warranted.
Authors
- Ana Catarina Ferreira (ORCID: https://orcid.org/0000-0003-3723-2086)
- Kyan Younes (ORCID: https://orcid.org/0000-0002-9912-1616)
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- Maya Yutsis
- Rowan Saloner (ORCID: https://orcid.org/0000-0002-1351-6183)
- Kaitlin Blackstone Casaletto (ORCID: https://orcid.org/0000-0001-5000-7604)
- Claire J. Cadwallader (ORCID: https://orcid.org/0000-0003-3449-3803)
- Jeffrey Zhu (ORCID: https://orcid.org/0000-0001-8578-3574)
- Victor W. Henderson (ORCID: https://orcid.org/0000-0003-1198-9240)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Hanxiao Liu (ORCID: https://orcid.org/0000-0001-8857-3732)
- Joseph M. Castellano
- Coty Chen
- Samuele F Petridis
Institutions
- Rush University Medical Center (US)
- Allen Institute for Brain Science (US)
- University Memory and Aging Center (US)
- Rush University (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-31
- DOI
- https://doi.org/10.64898/2025.12.24.25342952
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00