Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis

In patients with KOA, celecoxib plus duloxetine effectively mitigates chronic pain and improves anxiety and depressive symptoms without increasing adverse hepatic or renal effects. These findings support its use as a safe and effective treatment option.

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Publication Details

Journal
World Journal of Psychiatry
Published
2025-12-31
DOI
https://doi.org/10.5498/wjp.v16.i1.110298
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis

Qing Fang, Hao-Hao Liang, Xin. Liu, Liang Li et al.
World Journal of Psychiatry
Osteoarthritis Treatment and Mechanisms
article

Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis

Qing Fang, Hao-Hao Liang, Xin. Liu, Liang Li, Yin-Di Sun, Na Liu
article en

Abstract

In patients with KOA, celecoxib plus duloxetine effectively mitigates chronic pain and improves anxiety and depressive symptoms without increasing adverse hepatic or renal effects. These findings support its use as a safe and effective treatment option.

World Journal of PsychiatryVol. 16(1)
Xi'an Honghui Hospital (CN)
Quality Education
Openalex Percentile: Top 26%
Osteoarthritis Treatment and Mechanisms
DOIOpen Access PDFOpenAlex
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Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis — Qing Fang, Hao-Hao Liang, et al. · World Journal of Psychiatry (2025) | TGRS Research Map | TGRS