Diagnostic performance of gastrin-releasing peptide receptor-targeted positron-emission tomography in biochemically recurrent prostate cancer—a systematic review and meta-analysis

In the present meta-analysis, GRPR-targeted PET has comparable and promising diagnostic utility for BCR of prostate cancer compared to prostate-specific membrane antigen (PSMA) and conventional imaging. Nevertheless, the limited sample sizes of existing studies warrant large-sample prospective trials comparing GRPR-targeted PET with first-line modalities to validate its clinical diagnostic and therapeutic value.