Critical appraisal of transporter gene polymorphisms on metformin efficacy in type 2 diabetes mellitus

Abstract This critical appraisal reviews the article by Sidiq et al. on transporter gene polymorphisms and metformin efficacy in type 2 diabetes. The study strengthens evidence linking SLC22A1 and SLC47A1 variants to treatment response. We highlight the limited clinical use of genetic screening, particularly in low-resource settings, and call for inclusion of diverse populations and multi-omic approaches to enhance predictive value. Affordable genotyping and decision-support tools are essential for translating these findings into practice and advancing personalized diabetes therapy.