Safety and outcome of bedaquiline and delamanid-based longer oral regimen in Indian children less than 5 years with drug-resistant tuberculosis

BDQ and DLM-based regimens appear effective and generally well tolerated in treating DR-TB in children under 5. However, a longer course of treatment of over 18 months is required. Careful monitoring for side effects, especially QTc prolongation, remains critical.

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Publication Details

Journal
Lung India
Published
2025-12-31
DOI
https://doi.org/10.4103/lungindia.lungindia_266_25
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
Field-Weighted Citation Impact
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article

Safety and outcome of bedaquiline and delamanid-based longer oral regimen in Indian children less than 5 years with drug-resistant tuberculosis

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Lung India
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Safety and outcome of bedaquiline and delamanid-based longer oral regimen in Indian children less than 5 years with drug-resistant tuberculosis

Minnie Bodhanwala, Dhruv Gandhi, Daksha Shah, Varsha Puri, Suhani Jain, Sanjay K. Mattoo, Ira Shah, Ramsha Ansari
article en

Abstract

BDQ and DLM-based regimens appear effective and generally well tolerated in treating DR-TB in children under 5. However, a longer course of treatment of over 18 months is required. Careful monitoring for side effects, especially QTc prolongation, remains critical.

Lung IndiaVol. 43(1)
National Tuberculosis Institute (IN), Maharashtra State Board of Technical Education (IN), Bai Jerbai Wadia Hospital for Children (IN), New Delhi Tuberculosis Center (IN)
Good health and well-being
Openalex Percentile: Top 29%
Tuberculosis Research and Epidemiology
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