AI-POWERED SPECULAR IMAGE ANALYSIS FOR CORNEAL ENDOTHELIUM DYSTROPHY PROFILING

Human cornea consists of ‘5’ layers the thickest layer is stroma layer and densest layer is the endothelium layer, the hexagonal structured cells is occupied in the endothelium layer, The cell gets disturbed when dystrophies like fuch’s dystrophy (FD), advanced fuch’s dystrophy (AFD), posterior polymorphous corneal dystrophy, Irido corneal dystrophy (ICD), mild polymegathism, and corneal guttata (CG) encounters..Total ‘13’ images are acquired from specular microscope of different dystrophies from various patients and processed into the artificial intelligent convolution filter (AICF) algorithm, which extracts mean cell area of endothelium cell, elongation of endothelial cell, Heywood circularity of endothelial, and compactness of endothelial, hexagonality, standard deviation, co-efficient of variation of endothelium layer (layer 5). The mean cell area of images I1 to I13 varies in the range of 79.5 µm2 to 3485 µm2, elongation endothelial cell varies in the range of 3.11 µm2 to 3.98 µm2, compactness factor of endothelial cell ranges 0.62 µm2 to 0.93 µm2 and Heywood circularity factor ranges 0.8 µm2 to 1.98 µm2, coefficient of variation ranges 10 µm2 to 99 µm2 and hexagonality of endothelial cell 46.6 µm2 to 65.2 µm2 are meticulously calculated. These endothelial statistical parameters represent the healthy condition of endothelial layer.