Hyperglycemia exacerbates placental inflammation induced by <i>Porphyromonas gingivali</i> s‐lipopolysaccharide
Bacteria that drive periodontitis, or their products, can enter the bloodstream and reach the placenta. In a high-glucose environment, this exposure can intensify placental inflammation. This study aimed to determine whether exposure to a high-glucose milieu, combined with byproducts of periodontal bacteria, activates inflammatory pathways in the placenta. Our results demonstrate that a high-glucose environment amplifies the inflammatory response to periodontal bacteria in human placentas from both healthy pregnancies and those complicated by gestational diabetes mellitus. These findings advance our understanding of the connection between periodontitis and gestational diabetes mellitus and underscore the role of oral bacterial translocation in placental tissues during pregnancy.
Authors
- Sebastián E. Illanes (ORCID: https://orcid.org/0000-0001-5433-9315)
- Valeria Ramı́rez (ORCID: https://orcid.org/0000-0003-2748-4351)
- Anilei Hoare (ORCID: https://orcid.org/0000-0002-1617-6401)
- María José Bendek (ORCID: https://orcid.org/0000-0002-3493-0156)
- María Luisa Mizgier (ORCID: https://orcid.org/0000-0002-6396-8823)
- Lara J. Monteiro (ORCID: https://orcid.org/0000-0003-2078-380X)
- Marcela Tavera Hernández
- Alpdoğan Kantarci
- David Herrera
- Wilfredo González
- María José Vasquez
- Alejandra Chaparro
- Carolina Rojas
- Patricia Valdebenito
Institutions
- Universidad de Santiago de Chile (CL)
- Universidad Complutense de Madrid (ES)
- Harvard University (US)
- National University of Singapore (SG)
- Universidad de Los Andes, Chile (CL)
- British Society of Periodontology (GB)
- Universidad Andrés Bello (CL)
- University of Chile (CL)
Publication Details
- Journal
- Journal of Periodontology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/jper.70051
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00