Catheter-Related Bloodstream Infection with Rhizobium radiobacter and Pseudomonas oryzihabitans Co-Infection: A Case Report and Literature Review

<b>Background:</b> Catheter-related bloodstream infections (CRBSIs) caused by environmental organisms are uncommon, and polymicrobial cases are even rarer. <b>Methods:</b> We describe the first case of catheter-related bloodstream infection caused by two infrequent environmental organisms-<i>Rhizobium radiobacter</i> and <i>Pseudomonas oryzihabitans</i>-occurring as a co-infection. <b>Results:</b> The patient's occupation involved frequent exposure to moist, soil-contaminated environments. Although these bacteria are often considered contaminants, they are capable of causing invasive infections such as bacteremia, which can be life-threatening. <b>Conclusions:</b> This case underscores the emerging pathogenic potential of <i>R. radiobacter</i> and <i>P. oryzihabitans</i> co-infection, particularly in patients with underlying malignancies or end-stage renal disease who have indwelling vascular devices, and highlights the importance of considering occupational and environmental exposures in the differential diagnosis of unusual pathogens.