Active Vitamin D Insufficiency Accelerates Skeletal Aging via Oxidative Stress and p16-Mediated Senescence
Active vitamin D insufficiency accelerates skeletal aging <i>in vivo</i> through a pathway involving reactive oxygen species-DNA damage-p16/senescence-associated secretory phenotype. Antioxidants, vitamin D repletion, or p16 inhibition rescued bone loss, highlighting redox-senescence axes as potential therapeutic targets for osteoporosis.
Authors
- D GOLTZMAN
- Lu Chen (ORCID: https://orcid.org/0000-0002-1421-4056)
- Mingxin null Huang
- Wanxin null Qiao
- Dengshun null Miao
Institutions
- McGill University Health Centre (CA)
- Plastic Surgery Hospital (CN)
- McGill University (CA)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-12-25
- DOI
- https://doi.org/10.31083/fbl46123
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00