Modulation of the Apolipoprotein M/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms
We found that the APOM/S1P axis was dysregulated in Col4a3-/- podocytes. Targeting this pathway through APOM supplementation or S1P receptor 4 antagonism improved kidney function and reduced lipid accumulation by enhancing either cholesterol efflux or autophagy, respectively.
Authors
- Rachel Njeim (ORCID: https://orcid.org/0009-0000-0501-395X)
- Matthew Tolerico (ORCID: https://orcid.org/0000-0002-1891-1166)
- Alexis Sloan
- Robin Nathans
- Sandrine Ettou (ORCID: https://orcid.org/0000-0002-2535-8661)
- Stephen P. Berasi
- Armando J. Mendez (ORCID: https://orcid.org/0000-0003-1859-0822)
- Makoto Kurano (ORCID: https://orcid.org/0000-0002-2596-1145)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Robin L. Bolek
- Sandra Merscher
- Alessia Fornoni
- Arianna Carrazco
Institutions
- University of Miami (US)
- Pfizer (United States) (US)
- Centers for New Horizons (US)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1681/asn.0000000996
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43