Single-Cell Dissection of Fibroblast Heterogeneity in Diabetic Ulcers: Platelet-Rich Plasma (PRP) Therapy Activates Core Regenerative Programs via PLAGL1/RUNX2/ZKSCAN7 Networks
Fibroblasts drive diabetic ulcer healing <i>via</i> transcription factor-regulated functional networks. PRP accelerates tissue repair by modulating fibroblast ECM-related gene expression, with the 26-gene signature providing a promising foundation for novel diagnostic and therapeutic targets.
Authors
- M Z Chen
- Ju Tian (ORCID: https://orcid.org/0000-0003-2494-2679)
- Xiongjie null Li
- Zhenghao null He
- Lizhen null Zhang
- Chenyan null Long
- Zhijun null Luo
Institutions
- Guangdong Medical College (CN)
- Shantou University (CN)
- Zhongshan People's Hospital (CN)
- Shantou Central Hospital (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-12-18
- DOI
- https://doi.org/10.31083/fbl47450
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00