Low Intensity Ultrasound-facilitated exosome delivery promotes hippocampal neurogenesis in Alzheimer's disease
Intranasal hADSC-Exos combined with LIUS is safe, enhances brain delivery, and synergistically improves cognition and neurogenesis in AD mice. The Fos-Kcnj13 axis may mediate these effects, suggesting a promising noninvasive therapeutic strategy.
Authors
- Yudie Yan (ORCID: https://orcid.org/0000-0001-5006-0931)
- Chae-Yong Kim
- Muyun Xie
- Jingtong Su
- Yafei Kong
- Zhen Zhang
- Kihwan Hwang
- Guohao Yuan
- Chenchao Wang
- Hong Han
- Yi Fang
Institutions
- Fudan University (CN)
- Seoul National University Bundang Hospital (KR)
- Wuhan University (CN)
- Zhongshan Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
- First Hospital of China Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.brs.2025.103015
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Scholarship Council
- Natural Science Foundation of Liaoning Province