Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts

The limited structural diversity of dictamnine, a bioactive furoquinoline alkaloid, restricts its drug discovery potential. To address this, we designed novel quinolinone-embedded cyclic diaryliodonium salts. These platforms enable a one-pot alkynylation/cyclization cascade granting efficient construction of the dictamnine framework with structural diversity and enabling the late-stage functionalization of drug molecules.

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Publication Details

Journal
Organic Letters
Published
2025-12-31
DOI
https://doi.org/10.1021/acs.orglett.5c04904
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
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article

Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts

Daqian Zhu, Y. Chen, R Liu, Y. Li et al.
Organic Letters
Catalytic C–H Functionalization Methods
article

Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts

Daqian Zhu, Y. Chen, R Liu, Y. Li, Shijun Wen, Nemai Saha, Kaitao Huang, Zhenhan Yu
article en

Abstract

The limited structural diversity of dictamnine, a bioactive furoquinoline alkaloid, restricts its drug discovery potential. To address this, we designed novel quinolinone-embedded cyclic diaryliodonium salts. These platforms enable a one-pot alkynylation/cyclization cascade granting efficient construction of the dictamnine framework with structural diversity and enabling the late-stage functionalization of drug molecules.

Organic LettersVol. 28(2)
Sun Yat-sen University (CN), Guangdong Pharmaceutical University (CN), Nanfang Hospital (CN), First Affiliated Hospital of Guangdong Pharmaceutical University (CN), Sun Yat-sen University Cancer Center (CN), Nanfang College Guangzhou
Openalex Percentile: Top 32%
Catalytic C–H Functionalization Methods
DOISourceOpenAlex
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Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts — Daqian Zhu, Y. Chen, et al. · Organic Letters (2025) | TGRS Research Map | TGRS