KAT2A promotes NLRP3-mediated trophoblast pyroptosis in preeclampsia by the succinylation
Silencing of KAT2A inhibits trophoblast pyroptosis by downregulating NLRP3 expression, thereby alleviating PE. Mechanistically, KAT2A stabilizes NLRP3 by facilitating its succinylation at K21 site. These findings suggest that KAT2A may be a promising target for the treatment of PE.
Authors
- Qing Su (ORCID: https://orcid.org/0000-0002-7607-7341)
- Shaoping Huang
- Xuechun Li
- Yang Zhang
Institutions
- Fourth Hospital of Changsha (CN)
Publication Details
- Journal
- Hypertension in Pregnancy
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1080/10641955.2025.2609374
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00