Glymphatic system dysfunction in pediatric growth hormone deficiency evidenced by multiple MRI metrics
Our findings suggest that glymphatic dysfunction may be a pathological mechanism in pediatric GHD. Furthermore, our study demonstrates that CPV, PVS volume, and DTI-ALPS index could serve as multiple auxiliary biomarkers for assessing the glymphatic function in pediatric GHD.
Authors
- Long Qian (ORCID: https://orcid.org/0000-0001-8833-8038)
- Lili Lin (ORCID: https://orcid.org/0000-0001-9736-8220)
- Qiuli Chen (ORCID: https://orcid.org/0009-0002-0657-6222)
- Yi Pik Cheng (ORCID: https://orcid.org/0000-0001-7956-2476)
- Huaqiong Qiu
- Chengfen Deng
- Zhiyun Yang
- Shu Su
- Xiang Gao
- Shuzhen Huang
Institutions
- Sun Yat-sen University (CN)
- Peking University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2025-12-31
- DOI
- https://doi.org/10.21037/qims-2025-1108
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91