Age- and Sex-Adjusted Myocardial Flow Reserve Percentiles for Personalized Cardiovascular Risk Assessment
Age- and sex-adjusted MFR percentiles provide a reliable, clinically actionable measure of vascular health, improving cardiovascular risk stratification by better capturing age- and sex-related heterogeneity in vascular risk. Compared with traditional fixed-threshold approaches, MFR percentiles demonstrate improved predictive performance for cardiovascular risk assessment across diverse patient populations.
Authors
- Jiaming Liang (ORCID: https://orcid.org/0000-0001-7273-495X)
- R. Blankstein
- M. Di Carli
- Leandro N. Slipczuk (ORCID: https://orcid.org/0000-0003-3091-3735)
- Ludovic Trinquart (ORCID: https://orcid.org/0000-0002-3028-4900)
- René R. Sevag Packard (ORCID: https://orcid.org/0000-0002-8520-5843)
- Panithaya Chareonthaitawee (ORCID: https://orcid.org/0000-0002-3811-8712)
- Andrew Jeffrey Einstein (ORCID: https://orcid.org/0000-0003-2583-9278)
- Viet T. Le (ORCID: https://orcid.org/0000-0001-6659-5332)
- Ronny R. Buechel (ORCID: https://orcid.org/0000-0001-8064-8904)
- J. Hainer
- Mark I. Travin
- Wanda Acampa (ORCID: https://orcid.org/0000-0003-2187-4076)
- Leanne Barrett (ORCID: https://orcid.org/0000-0003-0667-8720)
- Simone Soares Brandão
- Stacey Knight (ORCID: https://orcid.org/0000-0003-0092-7327)
- Thomas L. Rosamond (ORCID: https://orcid.org/0009-0000-1417-8342)
- Erick Alexanderson
- PJ Slomka
- Diana M. Lopez (ORCID: https://orcid.org/0000-0003-0817-6951)
- Steve Mason
- D A M I N I Dey
- Sylvain Carre
- Brittany N Weber
- M A R K Lemley
- Mouaz H Al-Mallah
- Sanjay Divakaran
- Isabel Carvajal-Juarez
- Sharmila Dorbala
- Giselle Ramirez Orozco
- Daniel Berman
- Daniel Huck
- Lee Joseph
- Jenifer M Brown
- Samuel Wopperer
Institutions
- Tufts University (US)
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- West Los Angeles College (US)
- Tufts Medical Center (US)
- Houston Methodist (US)
- Albert Einstein College of Medicine (US)
- NewYork–Presbyterian Hospital (US)
- Harvard University (US)
- University of Kansas (US)
- University of California, Los Angeles (US)
- The University of Kansas Health System (US)
- Intermountain Medical Center (US)
- Presbyterian Hospital (US)
- Southwestern Medical Center (US)
- University Hospital of Zurich (CH)
- Montefiore Health System (US)
- Federico II University Hospital (IT)
- Mayo Clinic in Arizona (US)
- Instituto Nacional de Cardiología (MX)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-31
- DOI
- https://doi.org/10.64898/2025.12.30.25343223
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Pfizer
- AstraZeneca
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Alnylam Pharmaceuticals
- Recordati Rare Diseases
- Novo Nordisk
- Sun Pharma
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Biomedical Imaging and Bioengineering