Integrative Genetic Analysis of DPP4-Related Variants Reveals Risk Patterns for Type 2 Diabetes and Cardiometabolic Comorbidities

Variants within the DPP4 axis influence susceptibility to HTN and DYS in T2DM, with GAATGT and GACCGT emerging as robust haplotype markers. Notably, the risk conferred by DPP4 rs3788979 genotypes was modulated by lipid status: CT/CC were protective against hypertension alone but became risk factors when dyslipidemia co-occurred.

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Journal
Diabetes Metabolic Syndrome and Obesity
Published
2025-12-31
DOI
https://doi.org/10.2147/dmso.s577700
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00

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article

Integrative Genetic Analysis of DPP4-Related Variants Reveals Risk Patterns for Type 2 Diabetes and Cardiometabolic Comorbidities

Q. Xiao, Yongchao Qiao, Chao Zuo, Chuan Bai et al.
Diabetes Metabolic Syndrome and Obesity
Genetic Associations and Epidemiology
article

Integrative Genetic Analysis of DPP4-Related Variants Reveals Risk Patterns for Type 2 Diabetes and Cardiometabolic Comorbidities

Q. Xiao, Yongchao Qiao, Chao Zuo, Chuan Bai, Shuangxin Wu, Qi Chen, Nan Zhou
article en

Abstract

Variants within the DPP4 axis influence susceptibility to HTN and DYS in T2DM, with GAATGT and GACCGT emerging as robust haplotype markers. Notably, the risk conferred by DPP4 rs3788979 genotypes was modulated by lipid status: CT/CC were protective against hypertension alone but became risk factors when dyslipidemia co-occurred.

Diabetes Metabolic Syndrome and ObesityVol. Volume 18
Sun Yat-sen University (CN), Guilin Medical University (CN), Fifth Affiliated Hospital of Sun Yat-sen University (CN), Sun Yat-sen University Cancer Center (CN), Eighth Affiliated Hospital of Sun Yat-sen University
Sun Yat-sen University, Natural Science Foundation of Guangdong Province, Natural Science Foundation of Guangxi Province
Good health and well-being
Openalex Percentile: Top 24%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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Integrative Genetic Analysis of DPP4-Related Variants Reveals Risk Patterns for Type 2 Diabetes and Cardiometabolic Comorbidities — Q. Xiao, Yongchao Qiao, et al. · Diabetes Metabolic Syndrome and Obesity (2025) | TGRS Research Map | TGRS