Cisplatin Differentially Damages Mammalian Vestibular End Organs

Our study demonstrates cisplatin's potential to affect the vestibular end organs adversely and differentially. The saccule was uniquely susceptible in our mouse model, suggesting that it may be possible to screen for cisplatin-induced vestibulotoxicity by testing saccular function. While very little is known about the potential for progression of cisplatin-induced vestibulotoxicity, our results suggest vestibular dysfunction may continue to worsen after cessation of cisplatin treatment. We recommend that ongoing and future efforts at evaluating vestibular function in patients treated with cisplatin include monitoring and evaluation of otolith function.