Spinal Mincle activation as a new model of neuroinflammation-associated neuropathic pain: comparison with spinal nerve ligation

Spinal Mincle receptor activation via i.t. TDB induces persistent pain hypersensitivity in the absence of peripheral nerve injury, accompanied by a more rapid neuroinflammatory response than that observed in the SNL model. These findings support Mincle activation as a potential experimental model for neuroinflammationassociated neuropathic pain.