Tumor-associated neutrophils drive liver-specific metastatic progression in breast cancer through methionine metabolism mediated by methionine adenosyltransferase II alpha
Our work uncovers a neutrophil-driven, MAT2A-dependent activation of methionine metabolism as a critical metabolic mechanism fueling liver metastasis in BC. These findings position the TAN-MAT2A-methionine axis as a promising therapeutic target for the treatment of BCLM.
Authors
- Qiannan Zhu (ORCID: https://orcid.org/0000-0002-9502-478X)
- Yue Sun (ORCID: https://orcid.org/0000-0003-3129-5414)
- Shuang Zhen
- Xiaoming Zha
- Tian Ji
- Jue Wang (ORCID: https://orcid.org/0009-0003-6234-8627)
- Rui Chen
- Lifeng Huang
- Dongwei Xu
- Qi Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tcr-2025-aw-2278
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00