Activated RARα counteracts the effects of TACC1v25 on the differentiation and invasion of head and neck squamous cell carcinoma

TACC1v25 may be involved in cell differentiation, invasion, and migration in HNSCC cells, and the dissociation of activated RARα from TACC1v25 might partially counteract the effects of TACC1v25 in HNSCCs. It is possible that ATRA induces conformational changes and/or promotes nuclear translocation of RARα, which in turn reduces its interaction with TACC1v25 and modulates the downstream transcriptional effects. This may provide new ideas for treating HNSCCs.