Comprehensive Multi-Omics Analysis Identifies Lactylation-Related Gene RAN as a Novel Prognostic Biomarker and Therapeutic Target in Glioma

Our study established lactylation modifications as a crucial regulator of the TME and glioma progression. Through integrative multi-omics analysis and robust machine learning techniques, we determined that <i>RAN</i> was a novel lactylation-associated gene. <i>RAN</i> is a potent, independent prognostic biomarker that promotes glioma malignancy via the PI3K/AKT pathway. Our results demonstrate <i>RAN</i> as a prospective therapeutic target and establish a novel framework for individualized therapy for glioma.