Rapid urinary lipoarabinomannan test with laboratory-level sensitivity for tuberculosis detection: a performance evaluation
To the best of our knowledge, this study uniquely reports a rapid diagnostic test, plasmonic fluor-enhanced urinary lipoarabinomannan lateral flow assay (PF-LAM), outperforming an electrochemiluminescence-based laboratory assay. PF-LAM demonstrated promising analytical and diagnostic performance with minimal lot-to-lot variability, positioning it as a helpful tool for non-sputum tuberculosis diagnostics.
Authors
- Ige George (ORCID: https://orcid.org/0000-0002-1425-4488)
- Scott L. Crick
- Sumanth Gandra (ORCID: https://orcid.org/0000-0003-1482-0854)
- Morten Rühwald (ORCID: https://orcid.org/0000-0002-1597-441X)
- Lorraine Lillis
- Qisheng Jiang
- David S. Boyle
- Jingyi Luan
- Harisha Ramachandraiah
- Srikanth Singamaneni
- Marcos Perez
- Carolyn Duncan
Institutions
- FIND (CH)
- Washington University in St. Louis (US)
- Brighton Hospital (US)
- Digital Research Alliance of Canada
- University of Houston (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1128/spectrum.03042-25
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00