Adverse side-effects of antifibrotic drugs and outcome of treatment in idiopathic pulmonary fibrosis
The prevalence of drug-related AEs reported in the first 6 months of AFT in the patients from the EMPIRE IPF Registry was below that reported in randomized clinical trials and most real-world studies, but with a similar drug-related AE profile. Only a quarter of all reported AEs were mild, unlike in numerous published series, with most of AEs being mild to moderate. A negative correlation between drug-related AEs and the clinical outcomes was evidenced, which is opposite to the effect of AEs of targeted treatment in lung cancer.
Authors
- V Muller
- Vladimir Bartos
- Petra Ovesná (ORCID: https://orcid.org/0000-0002-3547-5896)
- M Koziar Vašáková
- Martina Doubková (ORCID: https://orcid.org/0000-0002-4955-4093)
- Amelia Szymanowska-Narloch
- M. Placková
- Katarzyna Lewandowska (ORCID: https://orcid.org/0000-0003-1647-5724)
- Martina Šterclová
- Mordechai Kramer
- Nesrin Mogulkoc
- Monika Zurkova
- Dragana Jovanovic
Institutions
- Semmelweis University (HU)
- Charles University (CZ)
- Masaryk University (CZ)
- Thomayer University Hospital (CZ)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/jtd-2025-130
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00