Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy
Our data suggest that THM exerts its anticancer potential by inducing TRIM38-dependent PANoptosis and it also has synergistic antitumor effects in combination with conventional anticancer strategies. THM will be a promising candidate drug used alone or in combination with other anticancer regimens for cancer treatment.
Authors
- Mengting Chen (ORCID: https://orcid.org/0000-0003-4782-6240)
- Ting Duan (ORCID: https://orcid.org/0000-0001-6694-4520)
- Lin Li (ORCID: https://orcid.org/0000-0002-0533-7783)
- Quan Gao
- Xinbing Sui
- Xiaoqing Gu
- Qinsong Sheng
- Lijun Jin
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Normal University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1186/s40164-025-00734-4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00