circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort

This time-resolved, precision-weighted analysis of public RNA-seq data reveals stable circRNA differences between key clinical groups (patients with severe COVID-19 and those with ARDS), improving detection and interpretability relative to single-timepoint tests and yielding a concise set of candidates suitable for mechanistic follow-up and potential biomarker development.