Universal Screening of Cytomegalovirus Viral Load by Low-Pass Whole-Genome Sequencing in First-Trimester Pregnancy: Clinical Validation
Quantification of CMV DNA during NIPS is an accurate and sensitive method for CMV viral load. This approach effectively stratifies risk for both primary maternal infection and cCMV, enabling identification of pregnancies that may benefit from antiviral therapy.
Authors
- Piet Claerhout
- Inge De Cuyper
- Koen Swaerts
- Frederik Van Hoecke (ORCID: https://orcid.org/0000-0001-8413-699X)
- Patrick Descheemaeker
- Adriaan Vanderstichele (ORCID: https://orcid.org/0000-0002-3984-2948)
- Pauline Herroelen (ORCID: https://orcid.org/0000-0001-8431-520X)
- G. Martens
- Elke Boone
- Dieter De Smet
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- Ghent University (BE)
- AZ Delta (BE)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/clinchem/hvaf159
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00