Rare Hyalinized Variant of Oral Fibroepithelial Lesion: Case Report and Review of the Literature

Benign fibroepithelial lesions of the oral cavity, commonly referred to as irritation fib-roma, traumatic fibroma, or focal fibrous hyperplasia, represent reactive proliferations ari-sing in response to chronic tissue injury. While their clinical and histopathological features are well established, hyalinized variants are exceptionally rare and sparsely documented in the literature. Here, we present a case of a hyalinized fibroepithelial lesion of the oral muco-sa, initially presenting as a nonspecific pedunculated nodular mass. The lesion was surgi-cally excised, and histopathological examination revealed dense collagen deposition with prominent hyalinization, confirming the diagnosis. A brief review of previously reported cases is also provided to highlight the diagnostic challenges and clinical implications of this unusual histological presentation. This report underscores the importance of considering hyalinized variants in the differential diagnosis of oral soft tissue lesions and reaffirms surgi-cal excision with elimination of irritative factors as the treatment of choice.

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Publication Details

Journal
Kapadokya Üniversitesi
Published
2025-12-31
DOI
https://doi.org/10.54995/asc.5.3.5
Primary Topic
Oral and Maxillofacial Pathology
Type
article
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article

Rare Hyalinized Variant of Oral Fibroepithelial Lesion: Case Report and Review of the Literature

Büşra Erşan Erdem, Gözde Serindere, Safiye Pelin Şahiner, Cansel Coşar et al.
Kapadokya Üniversitesi
Oral and Maxillofacial Pathology
article

Rare Hyalinized Variant of Oral Fibroepithelial Lesion: Case Report and Review of the Literature

Büşra Erşan Erdem, Gözde Serindere, Safiye Pelin Şahiner, Cansel Coşar, Figen Öngöz Dede
article en

Abstract

Benign fibroepithelial lesions of the oral cavity, commonly referred to as irritation fib-roma, traumatic fibroma, or focal fibrous hyperplasia, represent reactive proliferations ari-sing in response to chronic tissue injury. While their clinical and histopathological features are well established, hyalinized variants are exceptionally rare and sparsely documented in the literature. Here, we present a case of a hyalinized fibroepithelial lesion of the oral muco-sa, initially presenting as a nonspecific pedunculated nodular mass. The lesion was surgi-cally excised, and histopathological examination revealed dense collagen deposition with prominent hyalinization, confirming the diagnosis. A brief review of previously reported cases is also provided to highlight the diagnostic challenges and clinical implications of this unusual histological presentation. This report underscores the importance of considering hyalinized variants in the differential diagnosis of oral soft tissue lesions and reaffirms surgi-cal excision with elimination of irritative factors as the treatment of choice.

Kapadokya Üniversitesi
Ordu University (TR)
Good health and well-being
Openalex Percentile: Top 27%
Oral and Maxillofacial Pathology
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