Development and validation of a novel palmitoylation-related prognostic signature in head and neck squamous cell carcinoma

Our findings highlight the prognostic significance of PRGs in HNSCC and suggest their potential utility in guiding personalized treatment strategies. Specifically, the PRG-based risk model demonstrated superior predictive performance compared to conventional clinical factors, supporting its value in improving patient stratification. Furthermore, the associations with immune infiltration patterns and drug sensitivity indicate that PRGs may not only serve as prognostic biomarkers but also help identify patients who could benefit from targeted or immunotherapeutic approaches.