Comparison of the Effects of Hyaluronic Acid and Platelet-Rich Fibrin on Wound Healing

PRF showed a nonsignificant, yet consistent superiority in enhancing both bone and soft tissue healing parameters and HA have a significant impact on bone and soft tissue healing. However, although both agents seem to impact the healing cascade, the superior OPG expression in the PRF group indicates a potentially stronger anti-resorptive and osteogenic effect. However, further studies are required to comprehensively evaluate their long-term relationship with wound healing.

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Publication Details

Journal
Journal of Craniofacial Surgery
Published
2025-12-31
DOI
https://doi.org/10.1097/scs.0000000000012331
Primary Topic
Periodontal Regeneration and Treatments
Type
article
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article

Comparison of the Effects of Hyaluronic Acid and Platelet-Rich Fibrin on Wound Healing

Hayati Yüksel, Dilan Aykanat, Muhammet Bahaeddin Dörtbudak, Adalet Çelebi et al.
Journal of Craniofacial Surgery
Periodontal Regeneration and Treatments
article

Comparison of the Effects of Hyaluronic Acid and Platelet-Rich Fibrin on Wound Healing

Hayati Yüksel, Dilan Aykanat, Muhammet Bahaeddin Dörtbudak, Adalet Çelebi, Ezgi Eroğlu Çakmakoğlu
article en

Abstract

PRF showed a nonsignificant, yet consistent superiority in enhancing both bone and soft tissue healing parameters and HA have a significant impact on bone and soft tissue healing. However, although both agents seem to impact the healing cascade, the superior OPG expression in the PRF group indicates a potentially stronger anti-resorptive and osteogenic effect. However, further studies are required to comprehensively evaluate their long-term relationship with wound healing.

Journal of Craniofacial Surgery
Cairo University (EG), Bingöl University (TR), Mersin Üniversitesi (TR), Harran University (TR)
Openalex Percentile: Top 26%
Periodontal Regeneration and Treatments
DOISourceOpenAlex
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Comparison of the Effects of Hyaluronic Acid and Platelet-Rich Fibrin on Wound Healing — Hayati Yüksel, Dilan Aykanat, et al. · Journal of Craniofacial Surgery (2025) | TGRS Research Map | TGRS