Multi‐Molecular Logic Framework Based on Morse Code, ASCII Logic, and Beale's Cipher for Advanced Crypto‐Steganography

Molecular information coding (MIC) involves biomolecules to encrypt and transmit messages, remains in its early stages of development. This work presents a versatile molecular integration framework and a proof-of-concept multi-level security system that combines Morse code, ASCII code, and Beale's cipher through molecular logic computing, using a molecular dye-oligonucleotide platform (single-stranded DNA, duplex DNA, stem-loop, and G-quadruplex (G-4) structures). This study demonstrates the integration of nanotechnology with crypto-steganographic methods to visualize and decipher codes, embedding elementary logic operations into molecular signal transduction. Additionally, a graphical user interface (GUI) is developed for classifying elementary logic gates using a decision tree algorithm, providing researchers with an accessible tool for rapid prediction. The Morse code-mediated strategy enables static key generation using dots, dashes, and intervals, and dynamic key generation through a polyalphabetic cipher framework. In parallel, ASCII-based logic gate operations facilitate multi-key decryption of decimal values to recover hidden information. Furthermore, a multilayered hybrid cryptographic technique combining Beale's cipher with Morse code implemented via a pangramic codebook, establishes an exceptionally resistant system against brute-force attacks. These methods provide insights into the evolution of communication and highlight the importance of encryption without relying on highly complex materials or sophisticated instruments.

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Publication Details

Journal
Small
Published
2025-12-30
DOI
https://doi.org/10.1002/smll.202513587
Primary Topic
Advanced biosensing and bioanalysis techniques
Type
article
Field-Weighted Citation Impact
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article

Multi‐Molecular Logic Framework Based on Morse Code, ASCII Logic, and Beale's Cipher for Advanced Crypto‐Steganography

Ajith Manayil Parambil, Song Hu, Mohamed Nabeel Mattath, Yan Gao et al.
Small
Advanced biosensing and bioanalysis techniques
article

Multi‐Molecular Logic Framework Based on Morse Code, ASCII Logic, and Beale's Cipher for Advanced Crypto‐Steganography

Ajith Manayil Parambil, Song Hu, Mohamed Nabeel Mattath, Yan Gao, Jie Li, Yingying Lu, Shuo Shi, Tian‐Ming Yao, Rui‐Min Zang
article en

Abstract

Molecular information coding (MIC) involves biomolecules to encrypt and transmit messages, remains in its early stages of development. This work presents a versatile molecular integration framework and a proof-of-concept multi-level security system that combines Morse code, ASCII code, and Beale's cipher through molecular logic computing, using a molecular dye-oligonucleotide platform (single-stranded DNA, duplex DNA, stem-loop, and G-quadruplex (G-4) structures). This study demonstrates the integration of nanotechnology with crypto-steganographic methods to visualize and decipher codes, embedding elementary logic operations into molecular signal transduction. Additionally, a graphical user interface (GUI) is developed for classifying elementary logic gates using a decision tree algorithm, providing researchers with an accessible tool for rapid prediction. The Morse code-mediated strategy enables static key generation using dots, dashes, and intervals, and dynamic key generation through a polyalphabetic cipher framework. In parallel, ASCII-based logic gate operations facilitate multi-key decryption of decimal values to recover hidden information. Furthermore, a multilayered hybrid cryptographic technique combining Beale's cipher with Morse code implemented via a pangramic codebook, establishes an exceptionally resistant system against brute-force attacks. These methods provide insights into the evolution of communication and highlight the importance of encryption without relying on highly complex materials or sophisticated instruments.

SmallVol. 22(13)
VSB - Technical University of Ostrava (CZ), Shanghai Tenth People's Hospital (CN), Shanghai Traditional Chinese Medicine Hospital (CN), Seventh People's Hospital of Shanghai (CN), Pudong New Area People's Hospital (CN)
Peace, Justice and strong institutions
Openalex Percentile: Top 35%
Advanced biosensing and bioanalysis techniques
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