mRNA expression of NLRP3 and IL1B in inflammatory bowel diseases: a systematic review and meta-analysis
We found upregulation of both NLRP3 and IL1B mRNA in intestinal tissue of IBD patients, which highly correlated across 24 studies, reinforcing the role of the NLRP3 inflammasome in IBD and its potential as a therapeutic target.
Authors
- Paula I. Metselaar (ORCID: https://orcid.org/0000-0003-1529-2774)
- R Schilder
- Aletta D. Kraneveld
- Anje A. te Velde
- Andrew Y. F. Li Yim
Institutions
- Utrecht University (NL)
- Amsterdam Institute for Addiction Research (NL)
- GGD Amsterdam (NL)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1186/s12876-025-04566-8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00