Single-Cell Sequencing Uncovers a TMSB10-Expressing Fibroblast Subpopulation Driving Renal Fibrosis in Diabetic Nephropathy

This study identifies TMSB10 as a novel fibroblast-specific regulator of renal fibrosis in DN, acting through the TGF-β/SMAD pathway. These findings expand current understanding of fibroblast heterogeneity and highlight TMSB10 as a potential therapeutic target for DN and other fibrotic diseases. Limitations include validation in a limited sample size and the use of murine fibroblast models, warranting further confirmation in human primary cells.

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Publication Details

Journal
Diabetes Metabolic Syndrome and Obesity
Published
2025-12-01
DOI
https://doi.org/10.2147/dmso.s559695
Primary Topic
Chronic Kidney Disease and Diabetes
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article
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article

Single-Cell Sequencing Uncovers a TMSB10-Expressing Fibroblast Subpopulation Driving Renal Fibrosis in Diabetic Nephropathy

Liexiang Zhang, Zihan Qin, Xiaohong Xu, Ke Du et al.
Diabetes Metabolic Syndrome and Obesity
Chronic Kidney Disease and Diabetes
article

Single-Cell Sequencing Uncovers a TMSB10-Expressing Fibroblast Subpopulation Driving Renal Fibrosis in Diabetic Nephropathy

Liexiang Zhang, Zihan Qin, Xiaohong Xu, Ke Du, Yuepeng Fang, Xiaoli Huang
article en

Abstract

This study identifies TMSB10 as a novel fibroblast-specific regulator of renal fibrosis in DN, acting through the TGF-β/SMAD pathway. These findings expand current understanding of fibroblast heterogeneity and highlight TMSB10 as a potential therapeutic target for DN and other fibrotic diseases. Limitations include validation in a limited sample size and the use of murine fibroblast models, warranting further confirmation in human primary cells.

Diabetes Metabolic Syndrome and ObesityVol. Volume 18
Jiangsu University (CN), Shandong University (CN), Nantong University (CN), Affiliated Hospital of Nantong University (CN), Jinan Central Hospital (CN), Affiliated Hospital of Jiangsu University (CN), Second People's Hospital of NanTong (CN), Shandong Provincial Hospital (CN), Nanjing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 30%
Chronic Kidney Disease and Diabetes
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Single-Cell Sequencing Uncovers a TMSB10-Expressing Fibroblast Subpopulation Driving Renal Fibrosis in Diabetic Nephropathy — Liexiang Zhang, Zihan Qin, et al. · Diabetes Metabolic Syndrome and Obesity (2025) | TGRS Research Map | TGRS