Targeted Temperature Management after Resuscitation of Cardiac Arrest: A Review

Cardiac arrest (CA) is a leading cause of mortality worldwide, with cerebral injury resulting from hypoxia being its most significant complication. This condition is associated with low survival rates and unfavorable neurological prognosis. Cerebral injury following CA is a major contributor to both mortality and long-term disability. Recently, Targeted Temperature Management (TTM) has garnered considerable attention as a non-pharmacological treatment modality for brain protection, aiming to reduce hypoxia-induced damage and improve neurological outcomes following CA. This work aims to provide a comprehensive review of TTM following CA, focusing on its current status, underlying mechanisms, research advancements, and future prospects for clinical application.