Unlocking C–N Bond Formation via a Two-Photon ETU-FRET Relay with Near-Infrared Light
The first two-photon upconversion photocatalysis for challenging C-N bond formations was reported. A robust, recyclable NaYF<sub>4</sub>,Yb:Er/Co<sub>3</sub>O<sub>4</sub>/g-C<sub>3</sub>N<sub>4</sub> nanosheet platform operated under mild, aerobic conditions with near-infrared light via an ETU-FRET relay. Its utility was demonstrated in synthesizing anticancer JNK3 inhibitor precursors and the late-stage functionalization of ibuprofen, establishing a versatile new paradigm for accessing and modifying medicinally important molecules.
Authors
- Yuchen Zhu (ORCID: https://orcid.org/0000-0002-7432-7837)
- Yue Zeng (ORCID: https://orcid.org/0009-0009-1383-3849)
- Yukai Yao
- Jianjun Li (ORCID: https://orcid.org/0000-0002-3485-5379)
Institutions
- Chemical Synthesis Lab (SG)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1021/acs.orglett.5c05148
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00