IL1RL1 rs11685480 polymorphism is associated with IL-33/IL1RL1 pathway activity and asthma severity in a Japanese population
The IL1RL1 rs11685480 polymorphism is associated with severe asthma. This polymorphism increases IL1RL1 expression and decreases sST2 levels, intensifying type 2 inflammation. These results elucidate the mechanism by which this gene variant modulates the IL-33/IL1RL1 signaling axis.
Authors
- Keita Hirai (ORCID: https://orcid.org/0000-0003-1509-8066)
- Kunihiko Itoh (ORCID: https://orcid.org/0000-0003-4436-0529)
- Sekiko Uehara
- Saya Kobayashi
- Yuuka Ogasawara
- Taisuke Akamatsu
- Toshihiro Shirai
Institutions
- Shinshu University (JP)
- University of Shizuoka (JP)
- Shinshu University Hospital (JP)
- Shizuoka General Hospital (JP)
Publication Details
- Journal
- Respiratory Investigation
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.resinv.2025.101362
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00