In vitro evidence to support amphotericin B and flucytosine combination therapy for talaromycosis
Our study demonstrated in vitro evidence of synergistic activity between AmB and 5FC against T. marneffei, providing the evidence to support in vivo and clinical trial testing of AmB and 5FC combination therapy, and dosing reduction strategies of 5FC.
Authors
- Charles Giamberardino (ORCID: https://orcid.org/0000-0001-7813-5616)
- Lottie Brown (ORCID: https://orcid.org/0000-0001-9896-8682)
- Matthew H. Burke
- Shawin Vitsupakorn
- Nguyen Thi Mai Thu
- Heera Natesan Sambath
- JiaLin Liu
- K. Sreerama Reddy (ORCID: https://orcid.org/0000-0002-6745-4109)
- John Perfect
- Ngô Đình Hoà
- Emily Evans
- Thuy Le
Institutions
- Johns Hopkins University (US)
- Emory University (US)
- St George's, University of London (GB)
- University of Pittsburgh (US)
- Duke University (US)
- Pham Ngoc Thach University of Medicine (VN)
- Angkor Hospital for Children (KH)
- Johns Hopkins Medicine (US)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Duke University Health System (US)
- Oxford University Clinical Research Unit (VN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1371/journal.pntd.0013884
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00