miR-199a Knockdown Alleviates Insulin Resistance and Inflammation by Targeting DDIT4 via the PI3K/AKT Pathway in vitro and in vivo
Our findings reveal a novel miR-199a/DDIT4 axis that regulates insulin sensitivity and inflammation via the PI3K/AKT pathway, suggesting miR-199a as a potential therapeutic target for T2DM.
Authors
- Ling-Jia Tang
- Yuan Chen (ORCID: https://orcid.org/0000-0002-2368-0198)
- Yao Zhu (ORCID: https://orcid.org/0009-0000-6731-4475)
- Y. Cai
- Sen-Sen Ye
Institutions
- Ningbo No. 2 Hospital (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dmso.s549884
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningbo
- Hwa Mei Hospital, University of Chinese Academy of Sciences