Progression of albumin/creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) over 24 years in people with type 2 diabetes. Drivers, potential protectors and associated mortality
This study revealed several factors that are associated with accelerated progression of CKD over 20 + years, including female sex and current/previous smoking. At baseline, the group with ACR >3 mg/mmol exhibited the highest rate of ACR increase. Multiple factors influenced eGFR decrease in those with baseline eGFR ≥60 mL/min/1.73 m<sup>2</sup>. Mortality rate was profoundly influenced by historical CKD status.
Authors
- P. Kalra
- Abigail C. Lay (ORCID: https://orcid.org/0000-0001-5923-634X)
- Martin S. Gibson
- Hellena Hailu Habte‐Asres (ORCID: https://orcid.org/0000-0001-8141-1423)
- Liliana Shalamanova
- Andreas Matheou
- Martin Whyte (ORCID: https://orcid.org/0000-0002-2897-2026)
- Loren Wilkins
- SA White
- John Warner‐Levy
- Alexander Warner‐Levy (ORCID: https://orcid.org/0009-0008-1894-4233)
- Adrian H. Heald
- Orestis Zavlis
- Thomas McDonnell
Institutions
- Manchester Metropolitan University (GB)
- King's College London (GB)
- Salford Royal NHS Foundation Trust (GB)
- University of Surrey (GB)
- University of Manchester (GB)
- Salford Royal Hospital (GB)
- University College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1111/dme.70193
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00