L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications
This study validates the foundational L-relationship between average and SD of SF in which the uncertainty of seizure counts increased proportional to the number of seizures counted. When used for efficacy outcomes of trials, the statistical benefit of counting more seizures in participants with high SF was much greater than the increased challenge from higher uncertainty seizure counts. These results provide quantitative insights for SF-based inclusion criteria and statistical power calculations.
Authors
- W. Raymond Kerr
- Daniel M. Goldenholz (ORCID: https://orcid.org/0000-0002-8370-2758)
- Advith S. Reddy
- Neo Kok
- Lavanya Biju
- Jacqueline A. French
- Katherine N. McFarlane
Institutions
- Harvard University (US)
- University of Pittsburgh (US)
- Beth Israel Deaconess Hospital (US)
- Epilepsy Action (GB)
- Bethel University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/epi.70080
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Pfizer
- Beth Israel Deaconess Medical Center
- Sunovion
- LivaNova
- SK Life Science
- Eisai
- Angelini Pharma
- H. Lundbeck A/S
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke