Dysmenorrhea in Chronic Spontaneous Urticaria: A Subset of Patients Report Worsening and Partial Antihistamine Benefit: <scp>UCARE HURDLE</scp> ‐I Study
Although overall prevalence and severity of dysmenorrhea were similar in CSU patients and healthy controls, about one in five patients with CSU experienced worsening menstrual pain after disease onset, and only a subset of these patients reported partial improvement with antihistamines. A distinct CSU subgroup with heightened menstrual pain may be characterized by altered histamine dynamics. Whether these patients may benefit from more intensive antihistamine treatment remains uncertain and requires confirmation in future studies; further studies should explore neuroimmune and hormonal mechanisms underlying this overlap.
Authors
- Murat Türk (ORCID: https://orcid.org/0000-0002-3290-2661)
- Esen Özkaya (ORCID: https://orcid.org/0000-0002-9585-9509)
- Nazlı Caf (ORCID: https://orcid.org/0000-0001-9364-9236)
- Pelin Korkmaz (ORCID: https://orcid.org/0000-0002-0225-2485)
- Şakir Çınar (ORCID: https://orcid.org/0000-0002-1893-1116)
- Yasemin Erdem (ORCID: https://orcid.org/0000-0002-6597-2957)
- ÜMİT MURAT ŞAHİNER
- Hazal Kayıkçı (ORCID: https://orcid.org/0000-0003-4920-4752)
- Şule Çelik Kamacı (ORCID: https://orcid.org/0000-0001-7132-2400)
- Raif Coşkun (ORCID: https://orcid.org/0000-0001-5337-3511)
- Ragıp Ertaş (ORCID: https://orcid.org/0000-0002-9269-2619)
- N Cevik (ORCID: https://orcid.org/0000-0002-0621-4312)
- Aytul Zerrin Sin (ORCID: https://orcid.org/0000-0002-9199-1991)
- Uzm.dr. Deniz Özçeker
- Sevim Bavbek (ORCID: https://orcid.org/0000-0002-7884-0830)
- İnsu Yılmaz (ORCID: https://orcid.org/0000-0001-6023-6291)
- Derya Ünal (ORCID: https://orcid.org/0000-0001-9741-5939)
- Ö Özdemir
- Neslihan Demirel Öğüt (ORCID: https://orcid.org/0000-0001-5051-5481)
- Serpil Köylüce (ORCID: https://orcid.org/0000-0002-6755-9074)
- Emek Özgür KOCATÜRK
- Asli Akkor Gelincik (ORCID: https://orcid.org/0000-0002-3524-9952)
- Doç.Dr. Murat Borlu
- Ebru Damadoğlu (ORCID: https://orcid.org/0000-0001-6250-2100)
- Kasım Okan (ORCID: https://orcid.org/0000-0002-9743-4336)
- Eda Öksüm Solak (ORCID: https://orcid.org/0000-0002-1362-7801)
- Esra Adışen
- Zafer Türkoğlu (ORCID: https://orcid.org/0000-0002-4357-6646)
- Muhammed Burak Yücel (ORCID: https://orcid.org/0000-0003-0130-8229)
- Mehmet Gülengül (ORCID: https://orcid.org/0000-0002-8017-5729)
- Ece Tüsüz Önata (ORCID: https://orcid.org/0000-0002-0180-9093)
- Simge Ünal (ORCID: https://orcid.org/0000-0002-4226-0463)
- Hatice Eylül Bozkurt Yılmaz (ORCID: https://orcid.org/0000-0001-7499-8676)
- Bulent Enis Sekerel
- Özge Sevil Karstarlı
- Marcus Maurer
- Ragıp Fatih Kural (ORCID: https://orcid.org/0000-0001-5690-4090)
- Melisa Özay
- Merve Hörmet İğde
- Güler Yıldırım
- Semra Demir
- Ümmügülsüm Dikici
- Arzu Dilşat Zengin
- Özlem Su Küçük
- Rabia Öztaş Kara
- Elif Aktaş Yapıcı
- Elif Açar
- Özge Uysal Soyer
- Mustafa Tosun
- Torsten Zuberbier
- Erman Gıdık
Institutions
- Sakarya University (TR)
- Sivas Cumhuriyet Üniversitesi (TR)
- Bahçeşehir University (TR)
- Ankara University (TR)
- Usak University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Ege University (TR)
- Türkisch-Deutsche Universität (TR)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- Sivas State Hospital (TR)
- Sakarya Eğitim ve Araştırma Hastanesi (TR)
- Ankara Spine Center (TR)
- Kayseri Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Denizli Devlet Hastanesi (TR)
- Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic (TR)
- Pamukkale University (TR)
- Hacettepe University (TR)
- Istanbul University (TR)
- Charité - Universitätsmedizin Berlin (DE)
- University of Health Sciences Antigua (AG)
- Erciyes University (TR)
- Gazi University (TR)
Publication Details
- Journal
- International Journal of Dermatology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1111/ijd.70252
- Primary Topic
- Urticaria and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00